Summary & Conclusion

Summary

The LRP Study met both of its co-primary endpoints:

PATIENT

maxLCBI_4mm > 400
=
89% Higher Risk

After adjustment, the risk of experiencing non-culprit MACE event within 24 months is 18% higher with each 100 unit increase in maxLCBI_4mm.

Specifically, a patient with maxLCBI_4mm greater than 400 is at 89% higher risk than a patient with less than 400 maxLCBI_4mm

PLAQUE

maxLCBI_4mm > 400
=
322% Higher Risk

Risk of experiencing an event in a coronary segment within 24 months is 45% higher with each 100 unit increase in maxLCBI_4mm.

Specifically, a coronary segment with maxLCBI_4mm greater than 400 is at 322% higher risk than a segment with less than 400 maxLCBI_4mm

Conclusions

1

Intravascular NIRS imaging in mildly or non-obstructive coronary arteries can be used as a tool to identify both patients and non-culprit arteries at high risk for future events and should be considered for use in patients undergoing cardiac catheterization with possible percutaneous coronary intervention (PCI) procedures.

2

Imaging-related device events were observed in 0.4% of patients, therefore did not pose additional safety concerns outside of those that are known for percutaneous coronary intervention (PCI) procedures.

View The Lancet LRP Study